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TECHNOLOGY
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Patents & Intellectual Property


Ichor holds multiple patents that protect the innovative technology embodied in our TriGrid™ Delivery System and DNA drugs. The multidisciplinary research program undertaken by Ichor's team of scientists and engineers has led not only to the development of innovative solutions for DNA drug delivery, but also to the devices and procedures necessary for their safe, effective, and reproducible implementation in the clinic.

Ichor has filed and received several issued patents disclosing apparatus and methods of practice. In the broad field of electroporation-mediated drug delivery, we have achieved a dominant intellectual property position in the clinically important field of intramuscular delivery, and have established freedom to operate in other clinical applications, including intratumoral delivery.

Links to Published Ichor US Patents & Applications

US 8,108,040 - Method and apparatus for delivery of therapeutic agents
This patent includes claims covering devices in which the means for DNA vaccine administration and electroporation application are integrated into a single, automated device.

US 6,912,417 - Method and apparatus for delivery of therapeutic agents
Key features of the integrated application device enabling safe, effective, and reproducible electroporation mediated delivery which include: deployable electrodes, sharps injury protection, and device designs facilitating co-localization of the agent and electrical fields.

US 6,319,901 - Methods for prolonging cell membrane permeability
Methods for improving the efficiency of electroporation protocols as well as methods to enhance the permeabilized state, in order to improve the intracellular delivery of therapeutic substances.

US 6,278,895 - Electrodes and electrode arrays for generating electroporation inducing electrical fields
Electrode arrays for the in vivo application of electroporation wherein the conductive region of the electrodes comprising the array is controlled in order to confine the electroporation effect to a target region of tissue.

US 6,041,252 - Drug delivery system and method
A system for in vivo application of electroporation utilizing the simultaneous activation of three or more electrodes to allow improved uniformity in the electrical fields propogated within a target tissue.

US 5,873,849 - Electrodes and electrode arrays for generating electroporation inducing electrical fields
A highly adaptable electrode array system for in vivo application of electroporation, based on a grid of interlocking triangles.

US 6,117,660 - Method and apparatus for treating materials with electric fields having varying orientations (exclusively assigned)
Provides a method and apparatus for the delivery of membrane-containing materials with an added therapeutic agent using electrical fields. Electrical pulses are applied and routed using an electrode selection apparatus.

US 6,653,114 - Method and apparatus for treating materials with electric fields having varying orientations (exclusively assigned)
Provides a method and apparatus for the delivery of membrane-containing materials with an added therapeutic agent, in vitro, using electrical fields. Electrical pulses are applied and routed using an electrode selection apparatus.

WIPO Publications

PCT WO 2005/087311 (allowed) - Provides an apparatus for delivery of prophylactic and therapeutic agents to patients, using electrical fields to deliver such agents intracellulary in a safe, reproducible, efficacious, and cost effective manner.

PCT WO 03/086534 (allowed) - An electroporation delivery system wherein the means for agent administration and electric field application are integrated into a single, automated device.

PCT WO 00/4949A1 (allowed) - Electrode arrays for the in vivo application of electroporation comprising of electrodes with improved electrical and structural properties.