TECHNOLOGY & DEVICES

OVERVIEW2019-02-15T21:52:04+00:00

OVERVIEW

Electroporation (EP) utilizes the application of electrical fields in a target tissue to significantly increase intracellular nucleic acid uptake in the local area, resulting in enhanced gene expression compared to conventional methods of administration.

Muscle or skin cells in vivo

Nucleic Acid Administration

Electroporation Application

Intracellular DNA Uptake

Cell Recovery

Gene Expression

BENEFITS OF THE TRIGRID® DELIVERY SYSTEM

  •  Enhanced delivery of nucleic acid drug candidates
  •  Ease of use for clinical delivery of nucleic acid drugs
  •  Integrated and automated patented design
  •  Devices adapted for every phase of development from rodents to humans

APPLICATIONS

Ichor is developing strategic products by incorporating the TriGrid for delivery of nucleic acid candidates into two broad categories:

Nucleic Acid Vaccines / Immunotherapeutics
  • Alternative to traditional vaccine approaches
    • Prevention of Infectious Diseases
  • Immunotherapy / novel vaccine indications
    • Oncology
    • Chronic viral infection
    • Autoimmune disease, allergy
Protein / Monoclonal antibody (mAb) delivery
  • Alternative to systemic delivery of recombinants
    • Approved and/or novel agents
    • Low cost, sustained passive immunity (mAb)
  • Locoregional protein expression
    • Growth factors for revascularization / wound healing
    • Immunomodulators