OVERVIEW
Electroporation (EP) utilizes the application of electrical fields in a target tissue to significantly increase intracellular nucleic acid uptake in the local area, resulting in enhanced gene expression compared to conventional methods of administration.
Muscle or skin cells in vivo
Nucleic Acid Administration
Electroporation Application
Intracellular DNA Uptake
Cell Recovery
Gene Expression
BENEFITS OF THE TRIGRID® DELIVERY SYSTEM
- Enhanced delivery of nucleic acid drug candidates
- Ease of use for clinical delivery of nucleic acid drugs
- Integrated and automated patented design
- Devices adapted for every phase of development from rodents to humans
APPLICATIONS
Ichor is developing strategic products by incorporating the TriGrid for delivery of nucleic acid candidates into two broad categories:
Nucleic Acid Vaccines / Immunotherapeutics
- Alternative to traditional vaccine approaches
- Prevention of Infectious Diseases
- Immunotherapy / novel vaccine indications
- Oncology
- Chronic viral infection
- Autoimmune disease, allergy
Protein / Monoclonal antibody (mAb) delivery
- Alternative to systemic delivery of recombinants
- Approved and/or novel agents
- Low cost, sustained passive immunity (mAb)
- Locoregional protein expression
- Growth factors for revascularization / wound healing
- Immunomodulators